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A prospective observational study specifically examined adverse effects, including hematocrit elevations, of long-acting testosterone undecanoate; 347 hypogonadal men received a total of 3,022 testosterone undecanoate injections over 3. Mild side effects from ftm testosterone hrt. Sweating, headings, increased red blood cell count, increased sex drive, male pattern baldness, edema, increased body odor, increased hair growth, thinning of the hairline, soreness or a knot at the injection site if administered by intramuscular injection, acne, and mood changes. Testosterone, a hormone, helps men maintain muscle, bone health, libido, and the ability to perform in the bedroom. But beginning in their mid-30s, men lose an average of just under 2% per year. Perhaps some side effects from testosterone injections are due to an allergic reaction from the medication or the body is simply just getting used to having newly balanced levels of testosterone. 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